Synthesis spectral and antibacterial studies on few Semicarbazones of benzaldehyde derivatives

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The present paper describe synthesis, spectral and antibacterial investigations on tweleve semicarbazones derived from 2-Hydroxybenzaldehyde, 3-Hydroxybenzaldehyde, 4-Hydroxybenzaldehyde, 2-Chlorobenzaldehyde, 3-Chlorobenzaldehyde, 4-Chlorobenzaldehyde, 2-Nitrobenzaldehyde, 3-Nitrobenzaldehyde, 4-Nitrobenzaldehyde. 2-Methoxybenzaldehyde, 3-Methoxybenzaldehyde, 4-Methoxybenzaldehyde. The synthesized complexes have been characterized on the basis of IR, NMR and elemental analysis after checking purity. Antibacterial studies have been studied on staphylococcus aureus and order of antibacterial activity was found in the following order CBSC > MBSC H»HBSC > NBSC . The effect of structure and position of secondary group on antibacterial activity have also been investigated and in general it has been found that ortho effect reduces the antibacterial activity.

Antibacterial studies; Semicarbazones; Benzaldehyde derivatives