Synthesis and in vitro screening of some 1,3,4-oxadiazole derivatives as lipoxygenase inhibitors

Download this article as: 

1,3,4-oxadiazole derivatives of some classical Non Steroidal Anti-inflammatory Drugs were synthesized and investigated for the lipoxygenase inhibitory activity in vitro. The target compounds were obtained by cyclodesulfurization of the corresponding thiosemicarbazides using I2/NaOH. The intermediates were readily accessible through conversion of the carboxylic acid group to the respective acid hydrazides followed by treatment with phenyl isothiocyanate to yield corresponding thiosemicarbazides. The constitution of the products was confirmed by spectroscopic and elemental analysis. All the synthesized oxadiazole derivatives exhibited significant lipoxygenase inhibitory activity.

1,3,4-oxadiazole; Lipoxygenase inhibition; NSAIDs