Spectrophotometric methods for the determination of a Cephalosporin antibiotic in pharmaceutical formulations

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A simple, sensitive and reproducible visible spectrophotometric method is developed for the determination of Cefixime in pharmaceutical formulations. The Method is based on the formation of colored species on binding of Cefixime with Ferric chloride in 0.7 % HCl to produce a Yellowish green colored solution (lmax at 430 nm). Results of analysis were validated statistically and by recovery studies. This method is successfully employed for the determination of Cefixime in various pharmaceutical preparations.

Cefixime; Visible Spectrophotometric determination; Sandell’s sensitivity; Beer’s Law