Spectrophotometric method for the determination of Atorvastatin calcium in pharmaceutical formulations

S. VIJAYA SARADHI; G. DEVALA RAO; P.S.K. BHARGAV; B. RAMANA; K.R. MANIKANTA; G. PAVAN KUMAR

Article | Open Access

Spectrophotometric method for the determination of Atorvastatin calcium in pharmaceutical formulations

Volume 4, number 2

S. VIJAYA SARADHI^1*, G. DEVALA RAO², P.S.K. BHARGAV³, B. RAMANA³, K.R. MANIKANTA³ and G. PAVAN KUMAR³

¹Dept.of.Biotechnology, Koneru Lakshmaiah College of Engineering, Vaddeswaram - 522 502 (India).

²K.V.S.R. Siddhartha College of Pharmaceutical Sciences, (India).

³P.B.Siddhartha College of Arts and Science, Vijayawada - 520 010 (India).

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ABSTRACT:

A simple, sensitive and reproducible spectrophotometric method is developed for the determination of Atorvastatin calcium in bulk and in pharmaceutical formulations. This Method is based on the reaction of Atorvastatin calcium with Fe (III) of ferric chloride and Conc. hydrochloric acid to produce a yellow orange colored chromogen (λmax at 400 nm). Results of analysis were validated statistically and by recovery studies. This method is successfully employed for the determination of Atorvastatin calcium in various pharmaceutical preparations.

KEYWORDS:

Atorvastatin calcium; Visible Spectrophotometric determination; Beer’s Law

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Article Publishing History

Received on: April 25, 2007
Accepted on: August 21, 2007