Preparation and evaluation of solid dispersion of felodipine

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The main objective of the present study is to improve the dissolution rate of felodipine. In the present work an attempt was made to prepare solid dispersion (common solvent method) by using PEG4000 and PEG 6000 in the ration of 1:1, 1:2, 1:3, 1:4, 1:9 drug polymer ratio. The complexes were studied for the dissolution, the dissolution profiles shows that the drug excipient ratio of 1:9 gives higher dissolution rates than all the other ratios. Further PEG6000 gave faster dissolution rates of felodipine than the PEG4000 and obeys first order kinetics. The TLC of pure drug and PEG complexes had shown comparable Rf values and absence of additional spots. The IR spectrum of drug and solid dispersion found that in the functional group region except for peaks at 3300cm-1 wherein -OH and -NH of drug and PEG4000have merged to give a broad peak. The C=O peak of the drug has remained unchanged indicating the no change in the nature of the drug during formulation with PEG4000and also with PEG6000.

Preparation; evaluation; solid dispersion of felodipine