New bioactive metabolites isolated from sponge Hamigera hamigera
A Zagazig University, Faculty of Pharmacy, Pharamcognosy Department, Egypt. bInstitute of Pharmaceutical Biology, Heinrich-Heine-University, University Street 1, 40225 D?sseldorf, Germany.
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24 ethyl-5a-cholest-7-en-3a-ol (1), trans-P-hydroxycinnamaldehyde (2), para-hydroxybenzaldehyde (3), hamigeramine A (new alkaloid, 4) and Hamiguanasinol A (new nucleoside, 5) were isolated from the sponge Hamigera hamigera and their structures were established on the basis of UV data, NMR analysis and mass spectra. The extracts showed activity in fish feeding assay and were inactive in brine shrimp and antimicrobial assay.
KEYWORDS:Hamigera hamigera; sterols; nucleoside; alkaloids brine shrimp; fish feeding assay
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Article Publishing History
Received on: April 25, 2007
Accepted on: August 21, 2007
Accepted on: August 21, 2007
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