Hematological and histopathological behavior of Swiss albino mice against different dosage of diclofenac sodium

Download this article as: 

Diclofenac sodium belongs to the non steroidal anti inflammatory drugs (NSAIDS) and more especially to the phenyl acetic acid derivative. NSAIDS have been clinically used for their anti-inflammatory antipyretic & analgesic properties. It is widely believed that their therapeutic action is based on their ability to block the product of prostaglandin by their inhibitory effect against cyclo-oxygenate. The present study is based on hematological and histological toxicity presented by the use of NSAIDS (diclofenac). The present study has demonstrated that even a small dose of 0.1mg per kg body weight diclofenac orally can induce noticeable decrease in the blood parameter especially in RBC & Hemoglobin count. Intestinal mucosa has also shown histopathological changes and decrease in the number of crypts per circumference.

NSAIDS; (Non steroidal anti inflammatory drug); prostaglandin; crypt cells; cyclo-oxygenate