Effect of enhancers on permeation kinetics of ramipril for transdermal system

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Transdermal drug delivery system has seen a veritable explosion in the past decades. In the present scenario, very few transdermal patches are commercially available. Ramipril being an anti-hypertensive drug requires chronic administration. Since the drug has an extensive first pass metabolism. An attempt was made to develop transdermal drug delivery system for patient compliance. In this study, flux and permeation enhancement trials of ramipril was carried out using modified Franz diffusion cells through siloxane membrane for eight hours. hylouronidase as a permeation enhancer showed the best permeability as compared to sodium tauroglycholate, sodium lauryl sulphate etc. One long-standing approach for improving transdermal drug delivery uses penetration enhancers (also called sorption promoters or accelerants), which penetrate into skin to reversibly decrease the barrier resistance.

Ramipril; transdermal permeation studies