Design and in-vitro evaluation of Lisinopril transdermal patches containing Ethylcellusose-povidone as film formers

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The Matrix type TDDS of Lisinopril were prepared using different ratios of Ethyl cellulose (EC): Poly vinylpyrrolidone (PVP) (3:1, 2:3, 4:1, 1:2, 2:1, and 1:4) by solvent evaporation technique. Physicochemical parameters were characterized and dissolution studies of the formulated films were performed. In addition solubility studies at various pH, partition coefficient in octanol/water system, flux and enhancement ratio were also evaluated. In-vitro permeation studies were done using modified Franz diffusion cells through human cadaver skin utilizing 20%PEG 400 in normal saline. Permeation studies illustrated, 4% Hyaluronidase enzyme was a good enhancer. The prepared films were subjected to SEM and FTIR spectral analysis. Higuchi and Peppas model were used for optimizing the formulation.

Lisinopril;Transdermal Patches; PVP; EC; Permeability Study; Chemical enhancers; Optimization