Formulation Of Omeprazole Niosomes And Its Characterization

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In the present study an attempt has been made to prepare niosomes. The niosomes formulation has got various advantages over conventional dosage form; these persist in the blood for a longer time than conventional and can thus greatly improve the therapeutic effect of drug. The niosomes are prepared by Reverse phase evaporation technique using a homogenizer. Omeprazole was selected as candidate drug, since it has been one of the major antacid and antiulcer agents used in the treatment of various types of diseases associated with GIT. Niosomes are characterized for its size range, entrapment efficiency and invitro release of drug. For release study the phosphate buffer saline pH 8.6 was used and the samples were assayed spectrophotometrically at 306 nm. The data obtained proved that the formulation was useful for the controlled release of drug because percentage release after 24 hours was nearly to 100%.

Omeprazole; in vitro study; entrapment efficiency