Study Of Particle Size And Efficacy Of Transition Metal Complexes Of Mixed Ligands, Tolubutamide And Gliclazide, The Oral Antidiabetic Drugs

Arshi Siddiqui; S.A. Iqbal; S.S. Khan; Meena Iqbal

Article | Open Access

Study Of Particle Size And Efficacy Of Transition Metal Complexes Of Mixed Ligands, Tolubutamide And Gliclazide, The Oral Antidiabetic Drugs

Arshi Siddiqui¹*, S. A. Iqbal¹, S. S. Khan² and Meena Iqbal³

¹Department of Chemistry, Saifia College of Science and Education, Bhopal - 462 001 (India). ²Department of Microbiology, Saifia College of Science and Education, Bhopal - 462 001 (India). ³Asian Biotechnology Research Centre, Bhopal - 462 001 (India)

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ABSTRACT:

The present study describes the particle size determination of mixed ligand complexes of tolbutamide (TBM), N-[(Butyl amino) carbonyl] – 4 methyl benzene sulfonamide (trade name, Rastinon) and gliclazide (GCZ) 1-(3-Azabicyclo [3,3,0] oct-3yl) – 3- (p-tolyl-sulfonyl) urea (trade name Diamicron) are oral hypoglycemics which were synthesized with copper, zinc, mercury, iron and cobalt and suitably isolated in pure powdered form. Yields are substantial. Stoichiometry suggests 1:1:1 (L1L2M) ratio between drugs and metal ion, (ternary complexes). Analytical data of these complexes agrees with the compositions C12H17N2O3S-Cu-C15H20N3O3S, C12H17N2O3S-Zn-C15H20N3O3S, C12H17N2O3S-Hg-C15H20N3O3S, C12H17N2O3S-Fe-G5-H20N3O3S.2H2O, C12H17N2O3S-Co-C15-H20N3O3S.2H2O.

KEYWORDS:

Particle size; analysis; antidiabetic drugs; metal complexes

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