Effect of Metabotropic Glutamate Receptors II /III Agonists on Spike-Wave Discharge in Primary Somatosensory Perioral Cortex of Male WAG/Rij Rats
1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3Neurophysiology Research Center, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
4Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
5Department of Physiology, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran.
DOI : http://dx.doi.org/10.13005/bbra/2174
Download this article as:
The aim of this study was investigation of metabotropic glutamate receptors II/ III on spike-and-wave discharges in perioral somatosensory cortex of male WAG/Rij rats. Eighteen male WAG/Rij rats was used in this experiment. Rats anesthetized with a combination of ketamine and xilusinip and 2 μl of drugs injected with a 10 μl Hamilton syringe bilaterally. At the end of the experiment, all animals were killed by high dose of ketamine. The brain was removed rapidly and fixed in 10% formalin. Cresyl violet stained coronal sections were viewed with a light microscope to verify cannula placement. In all groups mean numbers and mean duration of Spike-and-wave discharges was decreased, but peak frequency was only in L-AP4 group was reduced. These agonists are able to suppress epileptic discharges in WAG/Rij rats and could be useful for treatment of Absence epilepsy in the future.
KEYWORDS:Metabotropic; Glutamate; WAG/Rij; Spike-and-wave; Perioral somatosensory cortex
PlumX:
Views: 92 Views 
PDF Downloads:
992 Accepted on: 07 August 2015
