Sodium Fluoride Induced Neurotoxicity and Possible Antioxidant Role of Selenium and Curcumin in Male Mice

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Selenium and Curcumin longa L are full of natural antioxidants. The aim of this study was to investigate the effect of sodium fluoride on antioxidant enzymes and the possible protective effects of selenium and Curcumin extract against the neurotoxicity and oxidative stress of sodium fluoride (NaF) that adversely affects antioxidant defense system especially in brain. Mature male mice (weighing 35-45 g and each group of ten animals) were given sodium fluoride (10.3 mg/Kg bw) and/or Selenium (0.5 mg/Kg) + Curcumin extract (60 mg/Kg) daily intraperitoneally (I.P) for 4 weeks. In the present study, Sodium fluoride induced oxidative stress by decreasing levels of SOD, CAT and increased MDA in the brain tissues which are ameliorated by Curcumin extract and/or selenium to great extent and thus improving the antioxidant defense capacities.

Sodium fluoride; Selenium; Curcumin extract; Brain; Neurotoxicity; Oxidative stress