Microbial Transformation of Bioactive Anthraquinones – A Review

Sadia Sultan^{1, 2}*, Nurunajah Ab. Ghani², 3, Syed Adnan Ali Shah¹, 2, Nor Hadiani Ismail², 3, Mohd Zaimi Noor¹, 2 and Humera Naz¹, 2*

1Department of Pharmacology and Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA(UiTM) Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor D.E., Malaysia. 2Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Level 9, FF3, Universiti Teknologi MARA (UiTM) Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor D.E., Malaysia. 3Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor D.E., Malaysia.

DOI : http://dx.doi.org/10.13005/bbra/1167

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ABSTRACT:

Anthraquinones, especially hydroxyanthraquinones, constitute one of the most ubiquitous classes of naturally occurring phenolic compounds. The hydroxyl and aminoanthraquiones show diverse physiological and pharmacological activity. Since pharmacological studies of small molecule bioactive compounds are known to be hampered by their weak solubility in water, it is important to prepare water-soluble analogues of hydroxy- and aminoanthraquinones by biotransformation. This review summarizes the glucosidation of substituted anthraquinones to achieve soluble analogues using fungi.

KEYWORDS:

Anthraquinone; biotransformation; fungi; glycoside

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