Synthesis, Analytical, Spectral and X-ray Diffraction Studies of Cu(II)andNi(II) Complexes with Glipizide, 1-Cyclohexyl3 [[p [2(5methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea, An Oral Antidiabetic Agent

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DOI : http://dx.doi.org/10.13005/bbra/1157

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ABSTRACT:

Complexes of transition metals like Cu(II) and Ni(II) with Glipizide1cyclohexyl 3[[p[2(5methyl pyrazine carboxamido) ethyl] phenyl] Sulphonyl] urea were synthesized. Metalcomplexes were characterized byelemental analysis, IR and NMR.The crystal structure of complexeswasdetermined by X-ray diffraction method. The XRD data was used to calculate various parameters like crystal system, volume, density, porosity, particle size etc.based on these studiestetrahedral geometry has been proposed for these complexes.

KEYWORDS:

Glipizide; Crystal structure; metal complex; IR; NMR; XRD