Dentistry is changing as we are now using modern science to practice dentistry. In comparison with classical medicine modalities such as antibiotics and disinfectants, ozone therapy is quite inexpensive, predictable and conservative. The ozone therapy has been more beneficial than present conventional therapeutic modalities. Treatment done with ozone reduces the treatment time as well as eliminates the bacterial count. Added, treatment is completely painless and increases the patient acceptability. Laboratory studies suggest a promising potential of ozone in dentistry, but less number of clinical studies were documented. Hence the focus should be on well designed double blind randomized clinical trial and establishment of safe and well defined parameters to determine the precise indications and guidelines for routine use of ozone in the treatment of various dental pathologies.