eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-05-06 8 2 801 805 9647 article Rajendra Jangde 1 Sanjay Daharwal 1 Ram Kumar Sahu 2 Anurag Rajvanshi 3 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur - 492 010 (India). Oriental College of Pharmacy, Raisen Road, Bhopal - 462 021 (India). Manav Bharti University, Laddo, Solan - 173 229 (India). The purpose of study was to evaluate the potential of microspheres for taste masking when incorporated into orally disintegrating tablets. The tablets were produced by simple wet granulation technique with a model compound (Ampicillin and Cloxacillin) which is moderately bitter. The formulating procedure had two variables to obtain good taste masking with desirable characteristics. It was found that ethyl cellulose was the best for masking the unpleasant taste of ampicillin and cloxacillin among the six kind of polymers investigated. The influences of other formulation factor, i.e. dichloromethane-acetone ratios and ethyl cellulose polymer ratios on the properties of microspheres were also examined. In conclusion, the results of the present study will be helpful for the preparation of oral forms of Ampicilin and Cloxacillin with an acceptable taste. https://www.biotech-asia.org/vol8no2/formulation-and-characterization-of-tasteless-dispersible-tablet-containing-ampicilin-and-cloxacillin/ Ampicilin; Cloxacillin; Microspheres; Taste masking