eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-05-06 8 1 337 340 9390 article Seema chaitanya Chippada 1 Sharan Volluri 1 Srinivasa rao Bammidi 1 Meena Vangalapati 1 Centre of Biotechnology, Department of Chemical Engineering, A.U. College of Engineering (A), Andhra University, Visakhapatnam - 530 003 (India). Centella asiatica is a valuable medicinal herbaceous aromatic creeper which has been valued for centuries in ayurvedic medicine. Phytochemical analysis of Centella asiatica plant extracts revealed the presence of various biochemical compounds such as alkaloids, flavonoids, glycosides, triterpenoids and saponins etc. Our present work aims at evaluating the in-vitro anti-thritic effect of Centella asiatica at various concentrations. The inhibition of protein denaturation and membrane stabilisation were taken as a measure of the in vitro anti-arthritic activity. The maximum percentage inhibiton of protein denaturation and membrane stabilisation for C. asiatica extracts ware found to be 89.76 % and 94.97 % respectively at a dose of 2000 μg/ml. Therefore, our studies support the isolation and the use of active constituents from Centella asiatica in treating arthritis. https://www.biotech-asia.org/vol8no1/in-vitro-anti-arthritic-activity-of-methanolic-extract-of-centella-asiatica/ Anti-arthritic activity; Centella asiatica; Diclofenac sodium; Triterpenoids; Flavonoids