eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-05-05 8 1 89 94 9237 article Ali Reza Shahsavar 1 Mohammad Javad Pourvaghar 2 Department of Physical Education Payame Noor University, 19395-4697 Tehran (Iran). Department of Physical Education University of Kashan, Kashan (Iran). The current research studies the response of immunoglobulins in blood serum to exhausting aerobic exercise. Twelve male students participated in this study. In the first stage, blood samples were drawn from the participants in a fasting state. Then, the participants performed Balke’s 15-minute run to the point of exhaustion. After the physical exercise, the second blood samples were drawn. The third blood samples were also drawn after 24 hours of rest. The comparison of concentration mean of immunoglobulin A in the first and second stages suggested a significant difference (P= 0.014). From the comparison of the second stage and the third stage, also a significant difference was noticed (P= 0.003). The comparison of concentration mean of immunoglobulin G after exhausting aerobic exercise revealed a significant difference (P= 0.001). After 24 hours of the participants’ rest, G immunoglobulins of serum revealed a significant difference (P= 0.014). Also, the comparison of immunoglobulins concentration between the first and second stages and also between the first and third stages suggested a significant difference. It can be said that in the current research, not only exhausting physical activity did not result in a decrease in immunity system, but also it caused the A, G, and M immunoglobulins concentration to increase significantly. As a result, one session of strenuous physical activity can strengthen the body’s immunity system. It seems that individual differences, the increase in catecholamine secretion, and also nervous and hormonal responses are some of the reasons behind the change in blood serum’s immunoglobulins. https://www.biotech-asia.org/vol8no1/a-follow-up-study-of-the-changes-in-some-immunity-factors-of-the-body-after-performing-one-session-of-exhausting-physical-exercise/ Immunity Factors; Physical Exercise; Balk Test