eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-05-06 7 2 933 937 9545 article Rashmi Kulkarni 1 Kiran Saxena 2 Meena Verma 3 Akhouri Sinha 4 Ajit Deshpande 5 Vandana Verma 6 Department of Biochemistry, 604, Adarsh Appartment, Sri Aurobindo Institute of Medical Sciences, Indore (India). Department of Biochemistry, College of Medical Sciences, Amargadh. Department of Biochemistry, MGM Medical College, Indore (India). Department of Biochemistry, Chirayu Medical College Hospital, Bhopal (India). Department of Community Medicine, Shri Aurobindo Institute of Medical Sciences, Indore (India). Department of Biochemistry MGM Medical College, Indore (India). To find out effect of antitubercular therapy on serum levels of Tumor necrosis factor alpha (TNF a) & Malondialdehyde (MDA). The present study was conducted in Department of Biochemistry and patients were selected from Department of TB and Chest Shri Aurobindo Institute of Medical sciences and amp; Manorama Raje Tuberculosis hospital, Indore. 32 healthy controls and 35 Pulmonary TB Patients were compared initially for serum MDA and TNF a levels. The serum TNF ? and MDA levels of PTB patients were again estimated after one month of antitubercular therapy. TNF ? & MDA levels in serum were significantly increased (p<0.001) in pulmonary tuberculosis patients when compared with control. Antitubercular therapy significantly decreases TNF a & MDA levels (p<0.05). The study indicates that TNF a and MDA are the important parameters in evaluating the severity of disease and monitoring of the clinical effect of the antituberculosis drugs (DOTS) over a period of prescribed drug therapy. https://www.biotech-asia.org/vol7no2/effect-of-antitubercular-therapy-on-serum-levels-of-tumor-necrosis-factor-alpha-and-malondialdehyde/ Tuberculosis; TNF alpha; malondialdehyde; antitubercular treatment