eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-05-02 6 2 585 592 8736 article V. Ravichandhran et al. 1 Department of Pharmaceutics,Vels College of Pharmacy, Pallavaram, Chennai (India). Pantoprazole is proton pump inhibitor, which prevent the production of acid in the stomach. Pantoprazole sodium enteric coated tablets were prepared by direct compression method. During this study the process parameters like granulation process, Compression process and Coating process are optimized by conducting the study with various blending time, blending speed, compression machine speed, pan speed, spray rate, spray gun distance to tablet bed, atomizing air pressure. Based on the evaluation results of various trials the optimum process parameters are selected (bending time-23min,blending speed- 6rpm, compression speed-30rpm, pan speed-9rpm, spray rate- 70ml/gun/min, spray gun distance to tablet bed- 24cm and atomizing air pressure-6kg/cm2). By using this optimized parameters the final batch was prepared it was subjected to evaluation. The results are correlated with the standard specified limits. https://www.biotech-asia.org/vol6no2/process-optimization-of-pantoprazole-sodium-enteric-coated-tablets/ pantoprazole sodium; process optimization; Granulation process; Compression process