eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-05-05 6 2 903 906 9130 article Mahesh Kumar Gupt 1 Surehdra N. Pandeya 2 Ashok Kumar 2 Galal-M. Ziad 3 Prabhat Engineering College, Kanpur-Dehat - 209 304 (India). Saroj Institute of Technology and Management, Lucknow - 226 002 (India) Al-Margeb University, Al-Khums, (Libya). Al-Margeb University, Al-Khums, (Libya). Bis-(N-p-chlorophenyl thioamido), bis-(N-phenyl thioamido) and bis-(N-tolyl thioamido) derivatives were tested for antibacterial activity against Staphylococcus aureus & Escherechia coli bacterial species. Antibacterial activity was measured by paper disc diffusion method. Inhibition zones indicated that 25 & 50 μg/ml of p-chloro derivative showed strong antibacterial activity against S. aureus and E. coli respectively. Synthesized compounds were also tested for antifungal activity against Candida albicans & Aspergillus niger fungal species. N-tolyl & N-phenyl derivatives showed good antifungal activity. https://www.biotech-asia.org/vol6no2/potent-antibacterial-activity-of-13-bisn-substituted-thioamido-guanidines/ Antimicrobial activity; 1 3-bis(N-substituted thioamido)guanidines