eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-04-27 6 2 537 540 8673 article Oloyede Omotade I. 1 Department of Biochemistry, University of Ado-Ekiti, Ekiti State (Nigeria). The effect of diabetes on glucose -6- phosphatase activity in selected tissues of rabbit was investigated. Rabbits were made diabetic by the administration of Alloxan (300mg/kg body weight) intraperitoneally. Fasting blood glucose level greater than 300mg/dl which persisted when untreated indicate Diabetes mellitus. Diabetic rabbits were treated with 100mg/kg body weight of aqueous extract from unripe pulp of Carica papaya. Result from normal and diabetic animals were compared with control administered distilled water only. In tissues of normal rabbit studied, liver, small intestine and stomach had a relative higher enzyme activity compared to the kidney. This is due to the fact that these organs especially liver and small intestine are highly involved in active transport processes and also useful for other purposes like regenerating glucose and ATP levels. Glucose-6-phosphatase activity increased significantly in the liver of diabetic animals. This shows that liver from diabetic rabbits exhibit increased glucose synthesis than normal animals which implies that Alloxan diabetes contributed to the elevation of this enzyme. https://www.biotech-asia.org/vol6no2/glucose-6-phosphatase-activity-in-selected-rabbit-tissues-of-normal-and-alloxan-induced-diabetic-rabbit/ Alloxan diabetes; Alloxan; ATP and Glucose-6-Phosphatase