eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-05-02 6 2 625 630 8768 article V. RavichandIran 1 Department of Pharmaceutics, Vels college of Pharmacy (India). Sustained release tablets of Quetiapine fumarate were prepared by wet granulation method using different polymers polymers HPMC K 4M , HPMC K 100M & EC in different ratios(F1 to F7)Dissolution was carried out in 0.1N Hcl & pH6.2 buffer. Dissolution tests are performed for successive batches and polymers were changed in each formulation. For seventh formulation maximum %Drug release was observed, in which ratio of two polymers HPMC K 4M & ETHYL CELLULOSE is 1:2. The % Drug release was very poor for polymers HPMC K 100M when compared to polymers HPMC K 4M & ETHYL CELLULOSE is 1:2.The dissolution profile of final batch(HPMC K 4M & ETHYL CELLULOSE 1:2.)compared with reference product which were found to be comparable with the reference product https://www.biotech-asia.org/vol6no2/formulation-and-evaluation-of-quetiapine-fumarate-sustained-release-tablets/ Quetiapine fumarate; HPMC K 4M; ethyl cellulose; Sustained release tablets