eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-05-03 6 2 773 778 8958 article Promita Datta Mohan Kulkarni 2 Department of Biochemistry, School of Life Sciences, North Maharashtra University,Jalgaon (India). Division of Biochemistry, Department of Chemistry, University of Pune, Pune (India). Antioxidant activity of Lycoperiscon esculentum fruit varieties in two different solvent fractions has been checked by different in vitro models. The methanolic fraction of S-22 variety showed significant antioxidant activity as well as it contained relatively higher amount of total phenolic and flavonoid compounds over Samrudhi variety. S-22 variety showed IC50 values as 115.92 μg/ml and 142.90 μg/ml to scavange DPPH; OH- and O2.- generation respectively. 1 gm of S-22 extract in methanolic fraction contained 35.27 mg phenolic compound equivalent to gallic acid and 36.83 mg flavonoid equivalent to quercetin respectively. Methanolic fraction in all the cases showed promising activity over aqueous fraction and may be due to the fact that antioxidant compounds were extracted more in methanol. https://www.biotech-asia.org/vol6no2/comparative-study-of-antioxidant-activity-of-fruits-of-lycoperiscon-esculentum-cultivars/ Antioxidants; Lycoperiscon esculentum; DPPH radical; Superoxide radical; Nitric oxide radical