eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-04-14 6 1 63 74 7847 article Zakaria K. Abd El-Samii 1 Said A. El Feky, 2 Hanan A. Abd El Fattah 3 Hanan A. Abd El Fattah 4 Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig (Egypt). The present investigation is concerned with the synthesis of different 2-methyl-4(3H)-quinazolinones with the objective of discovering novel and potent anti-inflammatory agents. Structures of the synthesized compounds were elucidated by spectral and elemental analyses. Some of the obtained compounds were evaluated for their anti-inflammatory activity as well as gastric ulcerogenic effects. Results showed that 2-[2-methyl-4-oxo-3(H)-quinazolin-3-yl]-N-(4-chlorophenyl-2-thiaoxothiazol-3-yl) acetamide (11 b) showed higher anti-inflammatory activity in carageenan-induced rat paw edema test with low gastric ulcerogenicity compared with indomethacin. Furthermore, molecular modeling studies were performed in order to rationalize the obtained biological results. https://www.biotech-asia.org/vol6no1/design-synthesis-and-molecular-modeling-study-of-quinazolin-43h-ones-with-potential-anti-inflammatory-activity/ 4(3H)Quinazolinone; anti-inflammatory; docking; COX-2