eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-04-16 6 1 301 30 8197 article Vasu Keshetty 1 Srinivas Pabba 1 Puligilla Shankaraiah 2 Allenki Venkatesham 1 SVS institute of Pharmacy, Ramaram, Warangal - 506 015 (India). Department of Pharmacy, Kakatiya University, Warangal - 506 009 (India). The present study is designed to evaluate the effect of methanolic extracts of Lagenaria siceraria on lipid profiles in Triton X-100 induced hyperlipidemia in male wistar rats. The fruit juice was obtained by crushing the fresh fruits of L. siceraria in the juicer and was subsequently dried in the oven at 40°-50°C. The parent dried juice extract was then fractionated by using the solvents according to polarity in ascending order i.e. by using chloroform: acetic acid, methanol, pyridine, and water. Each fraction was dried in oven at 40°-50°C. Thin layer chromatography (TLC) used active fraction obtained by column chromatography for further isolation and the isolated compounds (LS1, LS2 and LS3) were tested for anti-hyperlipidemic activity. All the extracts significantly increased (p < 0.0001) plasma HDL-Cholesterol and decreased plasma TC, LDL-Cholesterol and TG levels as compared with hyperlipidemic control. https://www.biotech-asia.org/vol6no1/antihyperlipidemic-activity-of-methanolic-extract-of-lagenaria-siceraria/ Lagenaria siceraria; lipid profile; Triton X-100; anti-hyperlipidemic