eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-04-16 6 1 261 264 8152 article Nadeem Siddiqui 1 M. Shamsher Alam 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) New Delhi - 110 062 (India) A number of new 5-(1H-indol-3-ylmethyl)-N-(substituted phenyl)-1, 2, 4-thiadiazol-2-amine derivatives (1-10) were synthesized and evaluated for their antibacterial and antifungal activity. The titled compounds (1-10) were obtained by cyclization of 2-(1H-indol-3-yl acetyl)-N-(substituted pheynyl) hydrazine carbothioamide in presence of conc. Sulphuric acid. The structures of newly synthesized compounds were characterized by spectral and elemental analyses. Compounds (1 and 4) showed 80% and 72% inhibition respectively against S. aureus while as compounds (2, 3 and 4) showed 76% inhibition against E.coli. Compounds (1, 4 and 8) showed 70%, 85% and 65% inhibition respectively against C. albicans. https://www.biotech-asia.org/vol6no1/5-1h-indol-3-ylmethyl-n-substituted-phenyl-1-2-4-thiadiazol-2-amine-derivatives-synthesis-and-biological-screening/ 1 3 4-thiadiazole derivatives;antimicrobial activity