eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-04-04 5 2 747 752 7533 article Ch.Narasimha Raju Bh 1 G. Devala Rao 2 Ramanjaneyulu Sikharam 3 A.S.N Pharmacy College, Burripalem Road, Tenali - 522 201 (India). G. Devala Rao St. Ann’s College of Pharmacy, Chirala (India). UV, second and third derivative spectrophotometric methods have been developed for the determination of Racecadotril in pharmaceutical formulation. The solutions of standard and sample were prepared in Methanol. For the first method, UV spectrophotometry, the quantitative determination of the drug was carried at 23l nm and the linearity range was found to be 8-100ug/ml.For the second and third derivative spectrophotometric methods the drug was determined at 250nm and 240nm with linearity ranges for both 8-100ug/ml .The calibration graphs constructed at their wavelength of determination were found to be linear for UV and derivative spectrophotometric methods. All the proposed methods have been extensively validated. The described methods can be readily utilized for the analysis of pharmaceutical formulation. https://www.biotech-asia.org/vol5no2/uv-and-two-derivative-spectrometric-methods-for-determination-of-racecadotril-in-tablet-formulation/ UV spectophotometry; derivative spectrophotometry; Racecadotril