eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-04-20 5 2 805 810 8398 article R.K.M. Mutahar 1 C. Nagesh 2 T.V. Narayana 1 S.C. Marihal 1 R. Ramesh 1 S.M. Nizami 1 P.G. Department of Pharmaceutics and Pharmacology. Dr. H.L.T.College of Pharmacy, Kengal, Channapatna, Bangalore (Rural) - 571 502 (India). P.G. Department of Pharmaceutics, S.C.S.College of Pharmacy, Harapanahalli (India). In the present research, an attempt has been made to formulate controlled release matrix tablets of nicotinic acid (NA), using xyloglucon (XGL), xanthan gum and guar gum separately, which tend to reduce “flushing” effect caused by immediate release of NA. Tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, in vitro dissolution and swelling index. All the formulations showed compliance with pharmacopoeial standards. After hydration of gum, drug release was essentially pH-independent. The amount released was directly proportional to the loading of dose and inversely proportional to gum concentration in tablets. Selected formulations were subject to stability studies, which showed stability with respect to release pattern. It can be concluded that, apart from guar gum, and xanthan gum the XGL can be successfully used as an effective matrix material to retard the release of NA for extended period of time. https://www.biotech-asia.org/vol5no2/formulation-and-in-vitro-evaluation-of-controlled-release-matrix-tablets-of-nicotinic-acid-using-xyloglucon-and-other-hydrphilic-polymers/ Nicotinic acid; Controlled release; Hydrophilic polymers; Xyloglucon; Gaur gum; Xanthan gum