eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-04-29 5 2 863 866 8684 article D. Ravi Kumar 1 V. Naga Lakshmi1 1 S.V.M.Vardhan 2 C. Rambabu 3 Two visible spectrophotometric methods have been developed for the quantitative estimation of Mirtazapine from its tablet formulations. The first method (method-A) is based on internal salt formation of red to violet colored chromogen of drug with citric acid – acetic anhydride which shows lmax at 580nm and linearity was observed in the concentration range of 8-40 μg.mL-1. The percentage recovery of drug from tablet formulation using this method was found to be in the range of 99.50-99.83 %. The second developed method (method-B) based on redox reaction of drug with Fe (III) – hexacyano ferrate (III) which shows lmax at 740 nm and linearity was observed in the concentration range of 5-25 μg.mL-1. The percentage recovery of drug from tablet formulation using this method was found to be in the range of 99.15-99.91 % Analysis of results for both developed methods were validated statistically. Recovery study results were close to 100%. The developed methods were found to be simple, rapid, accurate and repro9ducible. Both the methods are suitable for the estimation of mirtazapine from tablet dosage forms. https://www.biotech-asia.org/vol5no2/determination-of-mirtazapine-in-tablet-dosage-forms-by-visible-spectrophotometry/ Mirtazapine;hexacyanoferrate(III)