eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-04-25 5 2 849 852 8607 article Chlorcyclizine, an antihistamine, exhibiting antimetabolic activity and nonmutagenic behavior MUSFIQUA MOOKERJEE 1 NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, 124, B.L. Saha Road, Kolkata - 700 053 (India). Direct evaluation of the carcinogenicity of compounds, employing animal and tissue culture models are often dilatory, costly and less predictable. Opportunities for application of bacterial prescreens for their detection are being successfully explored because of the basic similarities of many of biochemical processes between the microbial and malignant mammalian cells. Several chemotherapeutic agents were screened employing two such bacterial prescreens for detecting their antimetabolic activity and subsequently determining mutagenicity, following Ame’s Test. From this study, Chlorcyclizine an antihistamine, structurally related to the phenothiazines emerged as a potential antimetabolite with nonmutagenic activity. Further invivo studies on malignant cell lines is suggested, with this promising drug chlorcyclizine to finally detect if it is endowed with anticarcinogenic property as well. https://www.biotech-asia.org/vol5no2/chlorcyclizine-an-antihistamine-exhibiting-antimetabolic-activity-and-nonmutagenic-behavior/

prescreens; antimetabolic activity; anticarcinogenecity; chlorcyclizine