Synthesis and pharmacological screening of novel 6-methyl-2-oxo-4-substituted-5-(5-phenyl-1, 3, 4-oxadiazole-2yl)-1, 2, 3, 4-tetrahydropyrimidine

eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-03-01 5 1 319 324 6831 article Synthesis and pharmacological screening of novel 6-methyl-2-oxo-4-substituted-5-(5-phenyl-1, 3, 4-oxadiazole-2yl)-1, 2, 3, 4-tetrahydropyrimidine S.S. Kshirsagar 1 B. V. Dhokchawle 1 S. S. Shinde 1 C. Thakare 1 H. Shewale 1 V. R. Shinde 1 S.N.D. College of Pharmacy, Babhulgaon, Yeola, Nasik - 423 401 (India) 1,3,4-oxadiazole derivatives prepared from DHPM has some antinflammatory and antibacterial activity. Drugs were synthesized and investigated for lipoxygenase inhibitory and in vitro antibacterial activity. The target compounds were obtained by synthesis of DHPM using substituted aldehydes and conversion of DHPM to the respective hydrazides followed by treatment with phosphorus oxychloride and dichloroethane to yield corresponding substituted (1, 3, 4-oxadiazole-2-yl)-1, 2, 3, 4-tetrahydropyrimidine-2(1H)-one, (3a-3h). The formation of the product was confirmed by spectroscopic and elemental analysis. Synthesized derivatives exhibited significant lipoxygenase inhibitory and antibacterial activity. https://www.biotech-asia.org/vol5no1/synthesis-and-pharmacological-screening-of-novel/ DHPM; 1 3 4-oxadiazole; Lipoxygenase