eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-03-04 5 1 377 382 6912 article S. M. Habibur Rahman 1 Chungath Thomas Telny 2 S. kuppusamy 3 Department of Pharmaceutics, PSG College of Pharmacy, peelamedu, Coimbatore (India) Department of Pharmaceutical Analysis, St. James College of Pharmacy, Chalakudy (India) Department of Pharmaceutics, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore (India) The goddess of curcumin gives color to life. Drug delivery approaches yet to be carried out to achieve the therapeutic benefit of phytoconstituent. Most of the herbal formulations emerging in the market are combination of phytomolecules1. Present study carried out to study the effect of Momordica charantia in curcumin formulation. Curcumin and Momordica charantia combination was widely used as anti-diabetic formulation. This combination is formulated as sustained release matrix tablets using HPMC and Ethyl cellulose by direct compression method. Formulated tablets were subjected to various in vitro evaluations; novel spectrophotometric method was developed and validated to quantify the Momordica charantia in the formulations.2 All formulation showed acceptable pharmacotechnical properties with excellent flow properties, in vitro release studies suggest that incorporation of Momordica charantia in curcumin formulations has no significant influence in the release profile. To conclude, the momordica charantia can be incorporated in curcumin formulations for its synergistic activity, in vivo studies can be carried out to claim the therapeutic effectiveness of the formulations. https://www.biotech-asia.org/vol5no1/influence-of-momordica-charantia-in-physical-properties-and-release-profile-of-curcumin-formulations/ Momordica charantia; Curcumin