eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-03-01 5 1 369 372 6861 article Amit Roy 1 S. Saraf 2 GRY Institute of Pharmacy, Borawan, Khargone - 451 228 (India) Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur- 492 010 (India) Alternanthera sessilis has been used to treat a wide assortment of diseases including diarrhea and dysentery (intestinal disorder), as a diuretic, as a cooling agent to treat fever, hepatitis, tight chest, bronchitis, asthma and lung troubles among others. We evaluated the diuretic activity of the chloroform insoluble fraction of defatted ethanolic extract of whole plant of A. sessilis (CIAE). Diuretic activity was determined in rats, by administering a single dose and thereafter determining the cumulative urine output. CIAE profoundly increased the cumulative urine out put (159.92%) compared to 142.09% increase by furosemide (13mg/kg). The extract altered the urinary pH. It also provoked a significant (p < 0.001) increase in urinary excretion of Na+ but lowered very slightly the excretion of K+, thus altering the Na+/K+ ratio, suggesting a potassium-sparing effect. The results justify the use of A. sessilis as diuretic agent in the traditional medicine https://www.biotech-asia.org/vol5no1/diuretic-activity-of-alternanthera-sessilis-r-br-ex-d-c-an-ethnomedicine-of-chhattisgarh-india/ Chhattisgarh; ethnopharmacology; Alternanthera sessilis; diuretic