eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-02-05 5 1 65 72. 6428 article Zeinab I. A. El- Sayed 1 Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University Zagazig (Egypt) C and GC/MS analysis of the essential oil isolated by hydro distillation of aerial part of Lamium maculatum L. showed the presence of thirty compounds which account for 99.9% of the total composition. Twenty four components representing (93.56%) of the oil were identified. The major components were found to be b- caryophyllene (14.80%), caryophyllene oxide (13.84%), Z, E- a- franesene (10.11%). dihydroedulan I (9.13%). a- humulene (6.06%), bornyl formate (6.03%) and a- bisabolene (5.34%). The oil showed moderate antimicrobial activity. Insecticidal activity of the essential oil was evaluated against the third larval instar of Musca domestica on the basis of mortality percentage. The obtained results declared the use of essential oil of Lamium maculatum L. as a natural insecticide. https://www.biotech-asia.org/vol5no1/chemical-composition-antimicrobial-and-insecticidal-activities-of-the-essential-oil-of-lamium-maculatum-l-grown-in-egypt/ Lamium maculatum L; Lamiaceae; essential oil composition; GC/MS; antimicrobial