eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-03-10 5 1 469 471 7037 article K. Ravi Shankar 1 B. Ganga Rao 1 Aditya Institute of Pharmaceutical Sciences and Research, Surampalem (India) The ethanolic extract of Gymnema sylvestre root was studied for anti-inflammatory activity against Oedema produced by carrageenan and histamine. The effect was compared with the activity of diclofenac sodium against the two types of inflammation. The ethanolic extract at doses of 100mg, 150 and 200mg/kg exhibited significant (P<0.001) anti inflammatory activity in inflammatory models. At 200mg/kg the ethanolic extract showed maximum inhibition of 39-75% in carrageenan-induced rat paw oedema while the standard diclofenac sodium inhibited 52-19% after 3 hr of carrageenan injection. The ethanolic extract (150, and 200mg/kg) significantly (P< 0.001) inhibited histamine induced rat paw oedema and the percentage inhibition is found to be 37.33% and 41.08% respectively all the results obtained suggest significant anti inflammatory activity of the extract. https://www.biotech-asia.org/vol5no1/anti-arthritic-activity-of-gymnema-sylvestre-root-extract/ Gymnema sylvestre; Anti-inflammatory; Carrageenan; Histamine