eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-02-05 4 2 773 776 6298 article N. Jahangeer 1 D. Venkappayya 2 M. N. Abubacker 3 P.G. and Research Department of Chemistry, Jamal Mohamed College, Tiruchirapalli - 620 020 (India) School of Chemical and Biotechnology, SASTRA University, Thanjavur - 613 402 (India) P.G. and Research Department of Botany, National College, Tiruchirapalli - 620 001 (India) Substituted cyclic ureas and thioureas having aliphatic homocyclic and heterocyclic rings were synthesized. They were screened for their antifugal activity against Cladosporium herbarum and Fusarium oxysporum.1,3 – Bis (morpholinomethyl) – imidazolidine 2- thione (MMIT) and COCl2.MMIT showed total inhibition to C.herbarum at 250, 500 and 1000 ppm concentrations, whereas 1,3-bis (morpholinomethyl)-2-imidazolidone (MMIZ) and ZnCl2.MMIZ showed total inhibition at 1000 ppm concentration towards C.herbarum. Against Fusarium oxysporum only ZnCl2.MMIT showed total inhibition at 1000 ppm concentration. Biosorption of metals on the mycelium of F. oxysporum were decreased in the other cases tried. https://www.biotech-asia.org/vol4no2/synthesis-and-antifungal-activity-of-1-3-bis-morpholinomethyl-2-imidazolidone-and-1-3-bis-morpholinomethyl-imidazolidine-2-thione-compounds/ 1 3-bis (morpholinomethyl) -2-imidazolidone (MMIZ) 1 3-bis (morpholinomethyl) imidazolidine – 2