eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-02-05 4 2 765 768 6281 article Saba K. 1 P. Umadevi 1 Department of Research, Jawaharlal Nehue Cancer Hospital and Research Centre, Idgah Hills, Bhopal - 462 001 (India) Diclofenac sodium belongs to the non steroidal anti inflammatory drugs (NSAIDS) and more especially to the phenyl acetic acid derivative. NSAIDS have been clinically used for their anti-inflammatory antipyretic & analgesic properties. It is widely believed that their therapeutic action is based on their ability to block the product of prostaglandin by their inhibitory effect against cyclo-oxygenate. The present study is based on hematological and histological toxicity presented by the use of NSAIDS (diclofenac). The present study has demonstrated that even a small dose of 0.1mg per kg body weight diclofenac orally can induce noticeable decrease in the blood parameter especially in RBC & Hemoglobin count. Intestinal mucosa has also shown histopathological changes and decrease in the number of crypts per circumference. https://www.biotech-asia.org/vol4no2/hematological-and-histopathological-behavior-of-swiss-albino-mice-against-different-dosage-of-diclofenac-sodium/ NSAIDS; (Non steroidal anti inflammatory drug); prostaglandin; crypt cells; cyclo-oxygenate