eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-02-02 4 2 567 574 5974 article B.G. Desai 1 A.R. Annamalai 2 B.M. Dinesh 1 K.S. Raghu 1 K. L. E. Society’s College of Pharmacy, II block, Rajajinagr, Bangalore - 560 010 (India) Anamalai University, Annamalai nagar, Chidambaram (India) The Matrix type TDDS of Lisinopril were prepared using different ratios of Hydroxy propyl methyl cellulose (HPMC): Poly vinylpyrrolidone (PVP) (3:1, 2:3, 4:1, 1:2, 2:1, and 1:4) by solvent evaporation technique. Physicochemical parameters were characterized and dissolution studies of the formulated films were performed. In addition solubility studies at various pH, partition coefficient in octanol/water system, flux and enhancement ratio were also evaluated. In-vitro permeation studies were done using modified Franz diffusion cells through human cadaver skin utilizing 20%PEG 400 in normal saline. Permeation studies illustrated, 4% Hyaluronidase enzyme was a good enhancer. The prepared films were subjected to SEM and FTIR spectral analysis. Higuchi and Peppas model were used for optimizing the formulation. https://www.biotech-asia.org/vol4no2/design-and-in-vitro-evaluation-of-lisinopril-transdermal-patches-containing-hpmc-and-pvp/ Lisinopril; Transdermal Patches; PVP HPMC; Permeability study Chemical enhancers