eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-02-02 4 2 541 550 5955 article Basavaraj hulkoti 1 Y. Anand Kumar 2 Uma A. Patil 1 B.M. Dinesh 2 K. L. E. Society’s College of Pharmacy, 2ndblock Rajajinagar, Bangalore - 560 010 (India) V.L.College of Pharmacy, Raichur (India) Matrix type TDDS of haloperidol were prepared using different ratios of Poly vinyl alcohol (PVA): Poly vinylpyrrolidone (PVP) (3:1, 2:3, 4:1, 1:2, 2:1, and 1:4) by solvent evaporation technique. Physicochemical parameters were characterized and dissolution studies of the formulated films were performed. In addition solubility studies at various pH, partition coefficient in octanol/water system, flux and enhancement ratio were also evaluated. In vitro permeation studies were done using modified Franz diffusion cells through human cadaver skin utilizing 20%PEG 400 in normal saline. Permeation studies illustrated, 4% hyaluronidase enzyme was a good enhancer. The prepared films were subjected to SEM and FTIR spectral analysis. Higuchi and Peppas model were used for optimizing the formulation. https://www.biotech-asia.org/vol4no2/design-and-in-vitro-evaluation-of-haloperidol-transdermal-patches-containing-pva-povidone-as-film-formers/ Haloperidol ; Transdermal Patches; PVP; PVA