eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-02-02 4 1 325 328 5801 article Gautam 1 A.K. Jain 1 Kuldeep Singh 1 Jagbir 1 V.K. Singh 1 Institute of Pharmacy Bundelkhand University, Jhansi - 284 128 (India) Synthesis of a number of 1,3,4 – oxadiazole derivatives have been described. Benztriazole reacting with ethylcholoro acetate in the presence of potassium carbonate to produce ethyl 2 – (1H benzo[d][1,2,3] triazol – 1 yl] acetate ) which further react with hydrazine hydrate to produced (2H-benzo [d][123] triazole – 1 yl aceto hydrazide ] and this react with different aromatic acid in presence of phosphorus oxychloriede offerda 2,5 disubstituted 1,3,4 oxadiazole derivatives. Compounds were tested for antibacterial and antifungal activity. https://www.biotech-asia.org/vol4no1/synthesis-and-biological-screening-of-25-disubstituted-134-oxadiazole-derivatives/ 1 3 4 – oxadiazole derivatives and antimicrobial activity.