eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-01-27 3 2 201 202 4389 article C.B.S. Dangi 1 N.C. Sharma 1 B.S. Dangi 2 Department of Genetics, Barkatullah University, Bhopal (India) Department of Biochemistry, RKDF Dental College and Research Centre, Bhopal (India) Thalassaemia is a major haemoglobinopathy of wide occurrence in the Indian sub-continent. It is distributed to different degrees in different sub-populations. The treatment of this disorder is quite expensive and counseling seems to be the only way for controlling it. Genetic analysis for Beta-thalassaemia blood disorder is detected by ARMS(Amplification Refractory Mutation System) tecnique. A total number of 43 cases obtain from OPD of Gandhi Medical College & Delta Pathology Bhopal were tested for this disorder. Out of seven common Beta thal mutation (D.J. Weatherall & J.B. Clegg), IVS1 nt 5 (G®C), IVS1nt 1(G®T), 619 bp deletion, Cap+1(A®C), -88 C®T,Fr 8-9(+G), Fr 41-42(-4bp) 39.52%, 16.27%, 18.59%, 6.97%, 0%, 0%, 0% respectively found in population of Bhopal. Early detection of thalassaemia is therefore important not only from treatment point of view, but also for the prevention by genetic counseling. https://www.biotech-asia.org/vol3no2/beta-thalassaemia-mutation-in-population-of-bhopal-central-india/ Beta-thalassaemia; Central India; Mutation; PCR; Genetic Counseling; Prenatal Diagosis