eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-01-11 3 1 71 72 3562 article Arshi Siddiqui 1 S.A. Iqbal 1 S.S. Khan 2 Meena Iqbal 3 Department of Chemistry, Saifia College of Science and Education, Bhopal - 462 001 (India) Department of Microbiology, Saifia College of Science and Education, Bhopal - 462 001 (India) Asian Biotechnology Research Centre, Bhopal - 462 001 (India) The present study describes the particle size determination of mixed ligand complexes of tolbutamide (TBM), N-[(Butyl amino) carbonyl] – 4 methyl benzene sulfonamide (trade name, Rastinon) and gliclazide (GCZ) 1-(3-Azabicyclo [3,3,0] oct-3yl) – 3- (p-tolyl-sulfonyl) urea (trade name Diamicron) are oral hypoglycemics which were synthesized with copper, zinc, mercury, iron and cobalt and suitably isolated in pure powdered form. Yields are substantial. Stoichiometry suggests 1:1:1 (L1L2M) ratio between drugs and metal ion, (ternary complexes). Analytical data of these complexes agrees with the compositions C12H17N2O3S-Cu-C15H20N3O3S, C12H17N2O3S-Zn-C15H20N3O3S, C12H17N2O3S-Hg-C15H20N3O3S, C12H17N2O3S-Fe-G5-H20N3O3S.2H2O, C12H17N2O3S-Co-C15-H20N3O3S.2H2O. https://www.biotech-asia.org/vol3no1/study-of-particle-size-and-efficacy-of-transition-metal-complexes-of-mixed-ligands-tolubutamide-and-gliclazide-the-oral-antidiabetic-drugs/ Particle size; analysis; antidiabetic drugs; metal complexes