eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2026-08-18 23 4 59558 article Janhavi Vishwas Gaikwad 1 Krushna Balu Dhumane 1 Yash Sonaram Choudhari 1 Harshal Parashram Chavan 1 Sunil Vilas Amrutkar 1 Department Of Pharmaceutical Chemistry, GES’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education and Research, Nashik, India Organic heteroatom compounds such as semicarbazides and thiosemicarbazides possess diverse structural features and important biological activities, including antimicrobial and anticancer properties. The presence of nitrogen and sulfur atoms enhances their interaction with biological targets, making them valuable scaffolds for drug development. Their nucleophilic and electrophilic centers enable the synthesis of novel derivatives through condensation reactions with ketones and carboxylic acids. Structural diversity among these compounds allows the generation of chemically varied molecules with promising ADME characteristics. In this study, derivatives were synthesized using an environmentally friendly microwave-assisted method, which provided advantages over conventional synthesis, such as shorter reaction time, higher yield, and reduced solvent waste. The synthesized compounds were characterized by elemental analysis, NMR, IR, and UV–Visible spectroscopy, confirming their structures and functional groups. Pharmacokinetic evaluation indicated acceptable solubility and compliance with Lipinski’s Rule of Five. The compounds were further evaluated for in vitro antimicrobial and anthelmintic activities, where several derivatives showed promising biological potential. To improve scientific clarity and impact, the presentation should include better organization and concise discussion of the main findings. Quantitative data such as percentage yield, reaction time reduction, biological activity values, and direct comparison between conventional and microwave-assisted methods would strengthen the overall scientific value of the study. https://www.biotech-asia.org/vol23no3/synthesis-spectral-characterization-infrarednuclear-magnetic-resonanceultraviolet-visible-and-biological-screening-of-novel-semicarbazide-and-thiosemicarbazide-compounds/ Anthelmintic Activity; Antibacterial Activity; Microwave; Pharmacokinetic parameter; Thiosemicarbazide