eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2026-08-21 23 3 59599 article Aparna Shrishail Bura 1 Priti Sharad Khilare 1 Kishor Vasant Otari 1 Ajay Yashwant Kale Department of Pharmacology, Navsahyadri Institute of Pharmacy, Pune, India Gastric cancer remains one of the leading causes of cancer-related mortality worldwide, largely due to delayed diagnosis, complex molecular mechanisms, and resistance to existing therapies. Although treatment options such as surgery, chemotherapy, and targeted therapy are available, their effectiveness is often limited by toxicity, adverse effects, and the development of drug resistance. Therefore, there is a growing need for safer and more effective therapeutic strategies. In recent years, plant-derived phytochemicals have gained considerable attention due to their relatively low toxicity and ability to target multiple molecular pathways. Compounds such as curcumin, resveratrol, epigallocatechin-3-gallate (EGCG), quercetin, berberine, luteolin, apigenin, sulforaphane, and ginsenosides have demonstrated notable anticancer potential, with promising results in preclinical studies and increasing evaluation in clinical settings. These bioactive molecules modulate key signaling pathways, including NF-κB, PI3K/Akt/mTOR, JAK/STAT3, MAPK, and Wnt/β-catenin, thereby suppressing inflammation and regulating oxidative stress, cell proliferation, apoptosis, angiogenesis, and metastasis. Furthermore, these phytochemicals have been reported to enhance the efficacy of conventional chemotherapeutic agents and reduce drug resistance, supporting their role in combination therapy. However, their clinical application remains limited due to poor bioavailability, rapid metabolism, lack of standardized formulations, and insufficient clinical evidence. Advances in nanotechnology-based delivery systems may help overcome these limitations and improve therapeutic outcomes. In conclusion, this review highlights the potential of phytochemicals as multi-targeted, low-toxicity agents in gastric cancer management and emphasizes their promise as adjuncts to current therapies. However, further well-designed clinical studies are essential to establish their efficacy and safety. https://www.biotech-asia.org/vol23no3/phytochemicals-targeting-inflammatory-signaling-pathways-to-combat-gastric-cancer/ Apoptosis; Chemosensitization; Gastric cancer; Herbal phytochemicals; Molecular signaling pathways; Oxidative stress; Targeted therapy