eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2026-07-14 23 3 59524 article Snehal Anil Khare 1 Abdul Kalam Abu Bakar 1 Shivraj Popat Jadhav 1 Deepak Devidas Sonawane 1 Department of Pharmaceutics, Divine College of Pharmacy, Nashik, India In this study, immediate-release Fimasartan tablets were formulated and optimised by use ofa 3² full factorial design with the objective of rapid disintegration and efficient drug release. Croscarmellose sodium (X₁) and microcrystalline cellulose (X₂) were selected as factors, while hardness (Y₁), disintegration time (Y₂), and drug release at 30 min (Y₃) were selected as responses. The tablets were formulated using the direct compression technique and subsequently assessed for both pre-compression and post-compression characteristics, along with disintegration performance and drug release profile. All prepared batches demonstrated satisfactory hardness, friability, uniformity of weight, and drug content values. Statistical analysis indicated that both variables significantly affected tablet performance. Increasing croscarmellose sodium reduced disintegration time and improved drug release, whereas higher MCC levels slightly prolonged disintegration and reduced release. Batch F7 was identified as the optimised formulation, showing hardness of 5.3 ± 0.2 kg/cm², disintegration time of 32 ± 2 s, and 99.8 ± 4.2% drug release at 30 min. Drug release followed first-order kinetics. Accelerated stability studies at 40 ± 2°C/75 ± 5% RH for three months showed no significant changes, and the similarity factor (f₂ = 74.13) confirmed comparable dissolution profiles. The study concluded that optimised immediate-release Fimasartan tablets were successfully developed using a factorial design. https://www.biotech-asia.org/vol23no3/optimization-of-immediate-release-fimasartan-tablets-using-3%c2%b2-factorial-design-for-rapid-disintegration-and-enhanced-drug-release/ Croscarmellose Sodium; Factorial Design; Fimasartan; Immediate-Release Tablets; Optimisation