eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2026-05-21 23 2 58943 article Bandekar Sankalp Nagesh 1 Zodape Gautam Vithobaji 2 Department of Zoology, S. S. AND L. S. Patkar College of Arts and Science, Patkar-Varde College, Mumbai, India Department of Zoology, V. P. Varde College of Commerce and Economics, Patkar-Varde College, Mumbai, India The present study evaluated the antimicrobial and antimycobacterial potential of crude leaf and fruit extracts of Garcinia indica, prepared as an ethanolic leaf extract (GiEE) and an aqueous fruit extract (GiAE). Antimicrobial activity was assessed against selected Gram-positive and Gram-negative bacteria, along with fungal strains, using minimum inhibitory concentration (MIC) determinations. Both extracts inhibited all tested microorganisms, with GiAE generally showing stronger activity than GiEE. Lower MIC values were observed against Staphylococcus aureus, Enterococcus faecalis, and Aspergillus niger, indicating notable antibacterial and antifungal efficacy. Antimycobacterial activity was further evaluated against Mycobacterium tuberculosis H37Rv using the Microplate Alamar Blue Assay. Both extracts exhibited significant inhibition, with GiAE demonstrating greater potency. Compared to standard antitubercular drugs, the activity of the crude extracts-particularly GiAE-was comparable to pyrazinamide. These findings suggest that Garcinia indica possesses broad-spectrum antibacterial, antifungal, and antimycobacterial properties. This study also provides the first evidence of its activity against M. tuberculosis, highlighting its potential as a natural source for developing new antitubercular and antibacterial agents. https://www.biotech-asia.org/vol23no2/studies-on-the-antibacterial-antifungal-and-antitubercular-potential-of-garcinia-indica-leaf-and-fruit-extracts/ Antifungal; Antimicrobial; Fruit; Garciniaindica; Leaves; Mycobacterium Tuberculosis