eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2026-06-24 23 2 59189 article Yash Sonaram Choudhari 1 Aditi Mangesh Metkar 1 Ritesh Sandeep Morankar 1 Sneha Krishna Poojari 1 Samiksha Shantaram Lokhande 1 Unmesh Gulabrao Bhamare 1 Department of Pharmaceutics, GES’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education and Research, Nashik, India In managing dental health, Periodontitis is a chronic infectious oral disease marked by inflammation, tissue degeneration, and tooth loss, which poses significant challenges. Traditional therapies often fail to achieve complete tissue regeneration and inflammation control. Consequently, natural products have garnered attention due to their antimicrobial, anti-inflammatory, antioxidant, and bone-protective qualities. Recently, plant-derived exosome-like nanoparticles (PELNs) have emerged as promising biocompatible and sustainable therapeutic agents. PELNs, which are naturally occurring extracellular nanovesicles (50-500 nm), contain bioactive substances such as proteins, lipids, and microRNAs derived from various plant parts, including fruits and roots, endowing them with regenerative, antioxidant, and anti-inflammatory properties. Research indicates that PELNs can enhance tissue regeneration in periodontal contexts, inhibit harmful bacteria like Porphyromonas gingivalis, and modulate immune responses. This chapter provides a comprehensive exploration of PELNs' biogenesis, composition, and therapeutic applications in managing periodontitis. It further discusses the future challenges and opportunities for integrating PELNs into clinical practice, highlighting their potential as a novel green nanomedicine through mechanisms of immune regulation, antimicrobial action, osteogenesis, and periodontal tissue regeneration, thereby offering a sustainable approach for preventing and treating periodontitis. https://www.biotech-asia.org/vol23no2/plant-derived-exosomes-a-green-nanomedicine-for-periodontitis-treatment/ Anti-inflammatory; Green nanomedicine; Nanoparticles; Periodontitis; Tissue regeneration