eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2026-03-30 23 1 160 179 10.13005/bbra/3488 58668 article Prachi Prashant Kage 1 Manoj Sharad Somvanshi 1 Angha Amit Sarvadnya 3 Rutuja Dnyaneshwar Patil 3 Anil Govindrao Jadhav 2 Atul Rupchand Bendale 3 Department of Pharmacology, Mahavir Institute of Pharmacy Nashik, India. Department of Pharmacognosy, Mahavir Institute of Pharmacy Nashik, India. Department of Pharmaceutical Chemistry, Mahavir Institute of Pharmacy Nashik, India. Hydrogels sensitive to temperature changes have begun to show promise as reliable materials for the controlled delivery of drugs, as they can systematically trap and release active agents based on changes in temperature. This review paper seeks to present the different facets of research undertaken in this field, including: the different types of polymers used in the creation of hydrogels, the various methods of polymerization, and the different methods of gelation, fabrication and characterization, strategies for the loading of drugs and the kinetics of drug release, the various fields of biomedical engineering where these materials can be applied (including the engineering of tissues, the transdermal delivery of drugs, the delivery of drugs to the eyes, and the treatment of tumour), work done in these fields in vitro and in vivo, the engineering of documentation, the safety and legal regulations involved in the engineering of these materials, as well as the engineering of the materials in the future. Each of the engineering challenges associated with these materials (e.g. the non-uniform size of the eluting agents, etc.) have associated engineering solutions, including systems with composites, hybrid hydrogels with endogenous carriers, and systems with multiple responsive domains. https://www.biotech-asia.org/vol23no1/thermosensitive-hydrogels-for-drug-delivery-systems-a-comprehensive-review/ Chitosan; Controlled Release; Drug Delivery; In Situ Gelling; Injectable Hydrogel; PNIPAM; Poloxamer; Stimuli-Responsive; Thermo-Responsive; Thermosensitive Hydrogel